Virus-induced Autoimmune Disease

Viruses have been implicated in this process among other etiol. After destruction of the supporting cells the related disintegrating sheaths are stripped. Current Topics in Microbiology and Immunology vol 206. The low frequency of autoimmune diseases in the population the familial nature and the HLA associations of these diseases suggest that a multifactorial control is. This article focuses on reviewing the role of viruses in initiation progression and perpetuation of autoimmune diseases. Oldstone MBA von Herrath M Evans CF Horwitz MS. In these mice insulin-dependent diabetes develops after either a viral infection the release of a cytokine such as IFN-γ or the expression of the costimulatory molecule B71 in the islets of Langerhans.

For example there is a transgenic murine model of virus-induced autoimmune disease in which a known viral gene is selectively expressed as a self-antigen in beta cells of the pancreas.

In these mice insulin-dependent diabetes develops after either a viral infection the release of a cytokine such as IFN-γ or the expression of the costimulatory molecule B71 in the islets of Langerhans. TMEV-induced demyelinating disease TMEV-IDD is considered to be a highly relevant animal model for the human autoimmune disease multiple sclerosis MS which is thought to be initiated as a secondary consequence of a virus infection. Eds Transgenic Models of Human Viral and Immunological Disease. For example certain viruses have a mitogenic affect on unique blood lymphocyte subsets and hence can act as polyclonal activators. Roles of LCMV in Delineating Mechanisms of Immune Tolerance Viral infections are a natural part of our existence. The studies summarized here indicate that viruses can serve as a trigger factor of autoimmune reactivity in various ways.

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Virus-induced autoimmune disease. Transgenic Approach to Mimic Insulin-Dependent Diabetes Mellitus and Multiple Sclerosis. Oldstone MBA von Herrath M Evans CF Horwitz MS. The presence of a threshold of relevant factors including circulating autoantibodies hypergammaglobulinemia female sex femalemale ratio 41 human leukocyte antigen HLA B8 DR3 or DR4.

For example there is a transgenic murine model of virus-induced autoimmune disease in which a known viral gene is selectively expressed as a self-antigen in beta cells of the pancreas. In these mice insulin-dependent diabetes develops after either a viral infection the release of a cytokine such as IFN-gamma or the expression of the costimulatory molecule B71 in the islets of Langerhans. For example certain viruses have a mitogenic affect on unique blood lymphocyte subsets and hence can act as polyclonal activators.

Various mechanisms by which virus infections can induce autoimmune responses including molecular mimicry epitope spreading direct. This chapter focuses on virus-induced autoimmune disease. Transgenic approach to mimic insulindependent diabetes mellitus and other autoimmune diseases.

The capacity to cause or exacerbate an autoimmune process is common to many viruses affecting mainly organs injured by the replicating virus as demonstrated by several animal models. AIH is diagnosed by the following. Current Topics in Microbiology and Immunology vol 206.

Viruses also direct the release of lymphokines and monokines. The studies summarized here indicate that viruses can serve as a trigger factor of autoimmune reactivity in various ways. Chisari FV Oldstone MBA.

Viral infections in humans commonly result in the transient appearance of a variety of autoantibodies and in some patients the development of autoimmune tissue injury and disease. Roles of LCMV in Delineating Mechanisms of Immune Tolerance Viral infections are a natural part of our existence. Virus-induced autoimmunity is a.

For example there is a transgenic murine model of virus-induced autoimmune disease in which a known viral gene is selectively expressed as a self-antigen in β cells of the pancreas. In these mice insulin-dependent diabetes develops after either a viral infection the release of a cytokine such as IFN-γ or the expression of the costimulatory molecule B71 in the islets of Langerhans.

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Myelin can be destroyed by injuries that affect either the myelin-supporting cells andor the myelin lamellae.

The precise mechanisms by which this can occur are mostly unknown. They can affect us in many ways that are the result of the interaction between the viral pathogen and our immune system. For example there is a transgenic murine model of virus-induced autoimmune disease in which a known viral gene is selectively expressed as a self-antigen in β cells of the pancreas. However when the host becomes infected with a virus encoding the same gene as the transgene or one closely related to it a resultant immune response directed against the virus also recognizes the transgene leading to progressive Tcellmediated response and destruction of the tissue expressing the viral self gene leading to autoimmune disease. Viruses have been implicated in this process among other etiol. Oldstone MBA von Herrath M Evans CF Horwitz MS. The breaking of tolerance or unresponsiveness to self-antigens involving the activation of autoreactive lymphocytes is a critical event leading to autoimmune diseases. Autoimmune Diseases etiology Carrier State immunology Cytotoxicity Tests Immunologic Fibroblasts immunology Leukemia Experimental etiology. The low frequency of autoimmune diseases in the population the familial nature and the HLA associations of these diseases suggest that a multifactorial control is.

Virus-induced autoimmunity is a. The virus per se is a self-replicating agent that provides a continuous supply of antigen and in most instances elicits a host immune response. 1996 Virus-Induced Autoimmune Disease. The presence of a threshold of relevant factors including circulating autoantibodies hypergammaglobulinemia female sex femalemale ratio 41 human leukocyte antigen HLA B8 DR3 or DR4. The studies summarized here indicate that viruses can serve as a trigger factor of autoimmune reactivity in various ways. In these mice insulin-dependent diabetes develops after either a viral infection the release of a cytokine such as IFN-γ or the expression of the costimulatory molecule B71 in the islets of Langerhans. Myelin can be destroyed by injuries that affect either the myelin-supporting cells andor the myelin lamellae.